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Terttm1Rdp
Targeted Allele Detail
Nomenclature
Symbol: Terttm1Rdp
Name: telomerase reverse transcriptase; targeted mutation 1, Ronald DePinho
MGI ID: MGI:3628579
Synonyms: mTert1-
Gene: Tert  Location: Chr13:73627001-73649041 bp, + strand  Genetic Position: Chr13, 40.12 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:108914
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExon 1, containing the ATG and encoding the RNA/DNA binding domain, was deleted. Activity of the mutant protein was not detected in the TRAP assay. (J:108914)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tert Mutation:  4 strains or lines available
References
Original:  J:108914 Farazi PA, et al., Cooperative interactions of p53 mutation, telomere dysfunction, and chronic liver damage in hepatocellular carcinoma progression. Cancer Res. 2006 May 1;66(9):4766-73
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory