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Yy1tm2Yshi
Targeted Allele Detail
Nomenclature
Symbol: Yy1tm2Yshi
Name: YY1 transcription factor; targeted mutation 2, Yang Shi
MGI ID: MGI:3625967
Synonyms: yy1flox
Gene: Yy1  Location: Chr12:108792973-108820148 bp, + strand  Genetic Position: Chr12, 59.58 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:108369
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Conditional ready, Hypomorph)
Mutation:    Insertion
 
Mutation detailsExon 1 and the promoter region were flanked with loxP sites by homologous recombination. An FRT-flanked neomycin cassette was inserted downstream of the 3' loxP site. Protein expression in heterozygotes is reduced by about 25% compared to wild-type mice. (J:108369)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Yy1 Mutation:  8 strains or lines available
References
Original:  J:108369 Affar el B, et al., Essential dosage-dependent functions of the transcription factor yin yang 1 in late embryonic development and cell cycle progression. Mol Cell Biol. 2006 May;26(9):3565-81
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory