Tpo^tee
Chemically induced Allele Detail

Summary

• Symbol: Tpo^tee
• Name: thyroid peroxidase; teeny
• MGI ID: MGI:3625284
• Gene: Tpo Location: Chr12:30104658-30182623 bp, - strand Genetic Position: Chr12, 13.0 cM, cytoband C
• Alliance: Tpo^tee page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A single T to A transversion in exon 11 substitutes an asparagine in place of a highly conserved tyrosine at amino acid position 614. (J:202956)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tpo Mutation: 50 strains or lines available

References

• Original: J:202956 Johnson KR, et al., Hearing impairment in hypothyroid dwarf mice caused by mutations of the thyroid peroxidase gene. J Assoc Res Otolaryngol. 2014 Feb;15(1):45-55
• All: 1 reference(s)