Phenotypes associated with this allele

• Allele Symbol: Tpo^tee
• Allele Name: teeny
• Allele ID: MGI:3625284
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tpo^tee/Tpo^tee	C57BL/6J-Tpo^tee/GrsrJ	MGI:5523782

Genotype
MGI:5523782

hm1

• Allelic Composition: Tpo^tee/Tpo^tee
• Genetic Background: C57BL/6J-Tpo^tee/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal thyroid gland morphology ( J:202956 )

• the thyroid glands of homozygotes are dysplastic with poorly developed follicles and hyperproliferation of epithelial cells

abnormal thyroid follicle morphology ( J:202956 )

• poorly developed follicles

abnormal thyroid gland development ( J:202956 )

small thyroid gland ( J:202956 )

• consistent with a lack of thyroid hormone synthesis

abnormal thyroid gland physiology ( J:202956 )

decreased activity of thyroid gland ( J:202956 )

• serum T4 is below the level of detection, less than 0.4 ug/dl, at 5 to 8 weeks of age

growth/size/body

proportional dwarf ( J:202956 )

• smaller size is evident by 1 week of age and persists throughout the life of the homozygote with the average body weight between 6 and 7 weeks of only 7.9 grams and at 12 weeks of age they weigh only approximately 10 grams

hearing/vestibular/ear

delayed inner ear development ( J:202956 )

• cochlear development is delayed such that at 7 days of age the inner sulcus has not formed, and the thickened tectorial membrane remains attached to large columnar epithelial cells, at 14 days of age the cochlea resembles that of a normal cochlea at 7 days of age with the inner sulcus formed and the tunnel of Corti and space of Nuel only beginning to form, and at 1 month of age the cochlea resembles a mature cochlea except the tectorial membrane remains abnormally thickened

abnormal cochlea morphology ( J:202956 )

abnormal tectorial membrane morphology ( J:202956 )

• delayed in its correct changes in development the tectorial membrane remains thickened

increased or absent threshold for auditory brainstem response ( J:202956 )

• ABR thresholds to broadband clicks and to 8, 16, and 32 kHz pure tone stimuli assessed at 1.5 months of age are highly elevated indicative of a 60-70 dB hearing loss, which is not statistically different from the hearing loss found in teeny 2 Jackson homozyogtes on a predominantly C57BL/6J background

limbs/digits/tail

abnormal femur morphology ( J:202956 )

• femurs of three assessed homozygotes were splayed at the distal end and appeared thicker than normal and undermineralized

skeleton

abnormal femur morphology ( J:202956 )

• femurs of three assessed homozygotes were splayed at the distal end and appeared thicker than normal and undermineralized

vision/eye

vision/eye phenotype ( J:202956 )

N • careful examination of the eyes of two homozygotes did not reveal any structural abnormalities