Gfra4^tm1Msa
Targeted Allele Detail

Summary

• Symbol: Gfra4^tm1Msa
• Name: glial cell line derived neurotrophic factor family receptor alpha 4; targeted mutation 1, Matti S Airaksinen
• MGI ID: MGI:3625130
• Gene: Gfra4 Location: Chr2:130881552-130885008 bp, - strand Genetic Position: Chr2, 63.26 cM
• Alliance: Gfra4^tm1Msa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108404
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2-5 were replaced with a neomycin resistance cassette. RT-PCR confirmed absence of transcript in mutants. (J:108404)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gfra4 Mutation: 9 strains or lines available

References

• Original: J:108404 Lindfors PH, et al., Ablation of persephin receptor glial cell line-derived neurotrophic factor family receptor alpha4 impairs thyroid calcitonin production in young mice. Endocrinology. 2006 May;147(5):2237-44
• All: 1 reference(s)