About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gfra4tm1Msa
targeted mutation 1, Matti S Airaksinen
MGI:3625130
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gfra4tm1Msa/Gfra4tm1Msa B6JHsd.129-Gfra4tm1Msa MGI:3628648
hm2
 		Gfra4tm1Msa/Gfra4tm1Msa involves: 129S1/Sv * 129X1/SvJ * C57BL/6JOlaHsd MGI:3628647


Genotype
MGI:3628648
hm1
Allelic
Composition		 Gfra4tm1Msa/Gfra4tm1Msa
Genetic
Background		 B6JHsd.129-Gfra4tm1Msa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfra4tm1Msa mutation (0 available); any Gfra4 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:108404 )
N
• no difference in thyroid calcitonin level in adult
• Background Sensitivity: thyroid tissue calcitonin content was not significantly different in newborn mutant mice in B6 background compared to wild-type control




Genotype
MGI:3628647
hm2
Allelic
Composition		 Gfra4tm1Msa/Gfra4tm1Msa
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6JOlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfra4tm1Msa mutation (0 available); any Gfra4 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
increased bone mineralization ( J:108404 )
• display a greater mineral apposition rate
increased bone ossification ( J:108404 )
• display a greater bone formation rate

endocrine/exocrine glands
abnormal thyroid gland physiology ( J:108404 )
• no difference in thyroid calcitonin level in adult
• Background Sensitivity: thyroid tissue calcitonin content was reduced by 80% in newborn mutant mice in 129/B6 hybrid background compared to wild-type control




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory