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Nle1tm1Cba
Targeted Allele Detail
Nomenclature
Symbol: Nle1tm1Cba
Name: notchless homolog 1; targeted mutation 1, Charles Babinet
MGI ID: MGI:3624778
Synonyms: mNl1-, Nlenull
Gene: Nle1  Location: Chr11:82900768-82908411 bp, - strand  Genetic Position: Chr11, 50.3 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:108385
Parent Cell Line:  CK35 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn NLS-LacZ construct was inserted in frame to replace exons 2 and 3. The first six amino acids of the endogenous protein fused to beta-galactosidase. (J:108385)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 3 assay results
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nle1 Mutation:  0 strains or lines available
References
Original:  J:108385 Cormier S, et al., The murine ortholog of notchless, a direct regulator of the notch pathway in Drosophila melanogaster, is essential for survival of inner cell mass cells. Mol Cell Biol. 2006 May;26(9):3541-9
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory