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Espl1tm1.2Kna
Targeted Allele Detail
Nomenclature
Symbol: Espl1tm1.2Kna
Name: extra spindle pole bodies 1, separase; targeted mutation 1.2, Kim Nasmyth
MGI ID: MGI:3624201
Synonyms: Separasedelta
Gene: Espl1  Location: Chr15:102296266-102324357 bp, + strand  Genetic Position: Chr15, 57.45 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:107916
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExons 24-31, including sequence encoding the catalytic dyad, were removed via cre mediated recombination. (J:107916)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Espl1 Mutation:  6 strains or lines available
References
Original:  J:107916 Wirth KG, et al., Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression. J Cell Biol. 2006 Mar 13;172(6):847-60
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory