Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Espl1tm1.2Kna mutation
(0 available);
any
Espl1 mutation
(95 available)
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Espl1tm1.1Kna mutation
(0 available);
any
Espl1 mutation
(95 available)
Espl1tm1.2Kna mutation
(0 available);
any
Espl1 mutation
(95 available)
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation
(2 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Wapltm1.1Jmpt mutation
(0 available);
any
Wapl mutation
(168 available)
Wapltm1.2Jmpt mutation
(0 available);
any
Wapl mutation
(168 available)
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cellular
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• tamoxifen-treated mouse embryonic fibroblasts exhibit diplo-chromosomes with unseparated arms unlike in control cells
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Espl1tm1.2Kna mutation
(0 available);
any
Espl1 mutation
(95 available)
Pttg1tm1.2Kna mutation
(0 available);
any
Pttg1 mutation
(16 available)
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mortality/aging
cellular
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• at E9.5 larger, lobed nuclei are seen in several organs, including the somites, heart, and brain
• after 10 days in culture MEFs have large lobed nuclei
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• 16 of 24 mitotic MEF cells had multipolar spindles and 8 were undergoing anaphase with lagging chromosomes
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• 16 of 24 mitotic MEF cells had multipolar spindles
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• extensive cell death is seen at E9.5
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embryo
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• irregular somites are seen at E10.5
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nervous system
growth/size/body