Nck2^tm3Paw
Targeted Allele Detail

Summary

• Symbol: Nck2^tm3Paw
• Name: non-catalytic region of tyrosine kinase adaptor protein 2; targeted mutation 3, Tony Pawson
• MGI ID: MGI:3623745
• Synonyms: Nck2^fl
• Gene: Nck2 Location: Chr1:43484643-43609678 bp, + strand Genetic Position: Chr1, 23.18 cM, cytoband C1
• Alliance: Nck2^tm3Paw page

Reduced inflammation in aortic roots obtained from tamoxifen-treated, high-fat diet fed Apoe^tm1Unc/Apoe^tm1Unc Tg(Cdh5-cre/ERT2)1Rha/0 Nck1^tm1Paw/Nck1^tm1Paw Nck2^tm3Paw/Nck2^tm3Paw mice.

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107630
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exon 1 was flanked with loxP sites. (J:107630)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nck2 Mutation: 29 strains or lines available

Notes

ES cell line = E14-ES (J:129166).

References

• Original: J:107630 Jones N, et al., Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes. Nature. 2006 Apr 6;440(7085):818-23
• All: 16 reference(s)