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Prokr2tm1Api
Targeted Allele Detail
Nomenclature
Symbol: Prokr2tm1Api
Name: prokineticin receptor 2; targeted mutation 1, Shunichiro Matsumoto
MGI ID: MGI:3623447
Synonyms: Pkr2-
Gene: Prokr2  Location: Chr2:132337733-132385447 bp, - strand  Genetic Position: Chr2, 64.15 cM
Prokr2tm1Api/Prokr2tm1Api mice, but not Prokr1tm1Api/Prokr1tm1Api mice, display olfactory bulb malformation

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:107587
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn exon containing the ATG start codon was deleted and a neo cassette in reverse orientation was inserted. Quantitative PCR confirmed ablation of the locus. (J:107587)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 14 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prokr2 Mutation:  22 strains or lines available
References
Original:  J:107587 Matsumoto S, et al., Abnormal development of the olfactory bulb and reproductive system in mice lacking prokineticin receptor PKR2. Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4140-5
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/11/2018
MGI 6.12
The Jackson Laboratory