About   Help   FAQ
Trpc6tm1Lbi
Targeted Allele Detail
Nomenclature
Symbol: Trpc6tm1Lbi
Name: transient receptor potential cation channel, subfamily C, member 6; targeted mutation 1, Lutz Birnbaumer
MGI ID: MGI:3623135
Gene: Trpc6  Location: Chr9:8544196-8680565 bp, + strand  Genetic Position: Chr9, 2.46 cM, cytoband A1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:106082
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaces exon 7, which encodes amino acids 584-670 comprising transmembrane domains 4 and 5 and a small part of the pore domain. Segments of mRNA upstream or downstream of the deletion cannot be amplified by RT-PCR from total lung RNA of homozygous mutant mice. (J:106082)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trpc6 Mutation:  35 strains or lines available
Notes
The reported phenotypes did not differ among mice from backcross generations N1 through N10 to C57BL/6J.

Trpc3 mRNA is elevated 3- to 5-fold in thoracic aorta and 2-fold in cerebral arteries of mutant mice compared to wild-type littermates, and Trpc7 mRNA is increased 2-fold in mutant cerebral arteries; levels of other Trpc mRNAs do not differ between mutant and control vessels.

References
Original:  J:106082 Dietrich A, et al., Increased vascular smooth muscle contractility in TRPC6-/- mice. Mol Cell Biol. 2005 Aug;25(16):6980-9
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/20/2017
MGI 6.10
The Jackson Laboratory