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Trpc6tm1Lbi
Targeted Allele Detail
Nomenclature
Symbol: Trpc6tm1Lbi
Name: transient receptor potential cation channel, subfamily C, member 6; targeted mutation 1, Lutz Birnbaumer
MGI ID: MGI:3623135
Gene: Trpc6  Location: Chr9:8544196-8680565 bp, + strand  Genetic Position: Chr9, 2.46 cM, cytoband A1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:106082
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaces exon 7, which encodes amino acids 584-670 comprising transmembrane domains 4 and 5 and a small part of the pore domain. Segments of mRNA upstream or downstream of the deletion cannot be amplified by RT-PCR from total lung RNA of homozygous mutant mice. (J:106082)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trpc6 Mutation:  27 strains or lines available
Notes
The reported phenotypes did not differ among mice from backcross generations N1 through N10 to C57BL/6J.

Trpc3 mRNA is elevated 3- to 5-fold in thoracic aorta and 2-fold in cerebral arteries of mutant mice compared to wild-type littermates, and Trpc7 mRNA is increased 2-fold in mutant cerebral arteries; levels of other Trpc mRNAs do not differ between mutant and control vessels.

References
Original:  J:106082 Dietrich A, et al., Increased vascular smooth muscle contractility in TRPC6-/- mice. Mol Cell Biol. 2005 Aug;25(16):6980-9
All:  20 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory