Tg(KRT14-Tslp)1Pcn
Transgene Detail

Summary

• Symbol: Tg(KRT14-Tslp)1Pcn
• Name: transgene insertion 1, Pierre Chambon
• MGI ID: MGI:3622662
• Synonyms: K14-TSLP, Tg(K14-Tslp)1Pcn
• Transgene: Tg(KRT14-Tslp)1Pcn Location: unknown
• Alliance: Tg(KRT14-Tslp)1Pcn page

Tg(KRT14-Tslp)1Pcn/0 mice develop a chronic skin inflammation

Show the 1 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(KRT14-Tslp)1Pcn expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tslp (MGI:1855696)

• Mutation details: This transgene expresses the murine Tslp gene under the control of the human keratin 14 promoter. Tslp expression is detected in the basal layer of the epidermis and some other KRT14-expressing epithelia such as in the tongue, eye and salivary gland. (J:102470)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:102470 Li M, et al., Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin. Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14795-800
• All: 4 reference(s)