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Nlrp3tm1Vmd
Targeted Allele Detail
Nomenclature
Symbol: Nlrp3tm1Vmd
Name: NLR family, pyrin domain containing 3; targeted mutation 1, Vishva M Dixit
MGI ID: MGI:3622094
Synonyms: Cias1-, Nalp3-
Gene: Nlrp3  Location: Chr11:59541569-59566956 bp, + strand  Genetic Position: Chr11, 37.73 cM, cytoband B1.3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:106976
Parent Cell Line:  C2 (Nagy) (ES Cell)
Strain of Origin:  C57BL/6NCrl
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1-3 were replaced with a neomycin resistance cassette. Exon 3 contains the ATG and the entire pyrin domain; exons 1 and 2 encode the 5' UTR. RT-PCR failed to detect transcript in mutants. (J:106976)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nlrp3 Mutation:  41 strains or lines available
References
Original:  J:106976 Mariathasan S, et al., Cryopyrin activates the inflammasome in response to toxins and ATP. Nature. 2006 Mar 9;440(7081):228-32
All:  87 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory