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Targeted Allele Detail
Symbol: Nod2tm1Vmd
Name: nucleotide-binding oligomerization domain containing 2; targeted mutation 1, Vishva M Dixit
MGI ID: MGI:3622092
Synonyms: Nod2-
Gene: Nod2  Location: Chr8:88647315-88688474 bp, + strand  Genetic Position: Chr8, 43.51 cM, cytoband C3
Germline Transmission:  Earliest citation of germline transmission: J:106976
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 3 was replaced with a PGK-neomycin resistance cassette. Stop codons in all 3 reading frames were introduced after the exon 3 splice acceptor site. Western blot failed to detect protein in mutants. (J:106976)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nod2 Mutation:  9 strains or lines available
Original:  J:106976 Mariathasan S, et al., Cryopyrin activates the inflammasome in response to toxins and ATP. Nature. 2006 Mar 9;440(7081):228-32
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory