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Targeted Allele Detail
Symbol: Ikbkgtm1Mka
Name: inhibitor of kappaB kinase gamma; targeted mutation 1, Michael Karin
MGI ID: MGI:3620102
Synonyms: Ikkgamma-, NEMO-
Gene: Ikbkg  Location: ChrX:74393290-74453854 bp, + strand  Genetic Position: ChrX, 38.0 cM
Germline Transmission:  Earliest citation of germline transmission: J:63054
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThis allele was created by using one of two vectors. The first vector was designed to insert a beta-lactamase cassette, a stop codon and a neomycin resistance gene in frame with the first ten codons. The second vector was designed to remove most of the coding sequence in the first exon and replace it with a beta-lactamase and neomycin resistance cassette. Western blot failed to detect protein in mutant ES cells. (J:63054)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ikbkg Mutation:  14 strains or lines available
Original:  J:63054 Makris C, et al., Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti. Mol Cell. 2000 Jun;5(6):969-79
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory