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Targeted Allele Detail
Symbol: S1pr3tm1Rlp
Name: sphingosine-1-phosphate receptor 3; targeted mutation 1, Richard L Proia
MGI ID: MGI:3620010
Synonyms: S1P3-, S1pr3-, S1pr3tm1Cys
Gene: S1pr3  Location: Chr13:51408639-51422797 bp, + strand  Genetic Position: Chr13, 26.12 cM, cytoband B1
Subcutaneous edema and thin endothelial cells in S1pr2tm1Rlp/S1pr2tm1Rlp S1pr3tm1Rlp/S1pr3tm1Rlp embryos

Show the 6 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:106055
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced part of the coding sequence. Northern blot confirmed absence of transcript in mutant brain, heart and lung samples. (J:106055)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any S1pr3 Mutation:  4 strains or lines available
Original:  J:106055 Kono M, et al., The sphingosine-1-phosphate receptors S1P1, S1P2, and S1P3 function coordinately during embryonic angiogenesis. J Biol Chem. 2004 Jul 9;279(28):29367-73
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory