About   Help   FAQ
S1pr3tm1Rlp
Targeted Allele Detail
Nomenclature
Symbol: S1pr3tm1Rlp
Name: sphingosine-1-phosphate receptor 3; targeted mutation 1, Richard L Proia
MGI ID: MGI:3620010
Synonyms: S1P3-, S1pr3-, S1pr3tm1Cys
Gene: S1pr3  Location: Chr13:51408639-51422797 bp, + strand  Genetic Position: Chr13, 26.12 cM, cytoband B1
Subcutaneous edema and thin endothelial cells in S1pr2tm1Rlp/S1pr2tm1Rlp S1pr3tm1Rlp/S1pr3tm1Rlp embryos

Show the 6 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:106055
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced part of the coding sequence. Northern blot confirmed absence of transcript in mutant brain, heart and lung samples. (J:106055)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any S1pr3 Mutation:  4 strains or lines available
References
Original:  J:106055 Kono M, et al., The sphingosine-1-phosphate receptors S1P1, S1P2, and S1P3 function coordinately during embryonic angiogenesis. J Biol Chem. 2004 Jul 9;279(28):29367-73
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/18/2020
MGI 6.14
The Jackson Laboratory