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| Caption | Histological analysis of S1pr2tm1Rlp/S1pr2tm1Rlp S1pr3tm1Rlp/S1pr3tm1Rlp embryos. A: Littermate control S1pr2tm1Rlp/S1pr2+ S1pr3tm1Rlp/S1pr3tm1Rlp (S1P 2+/- S1P 3-/-) embryo at E13.5. B: S1pr2tm1Rlp/S1pr2tm1Rlp S1pr3tm1Rlp/S1pr3tm1Rlp (S1P 1-/- S1P 3-/-) double homozygous mutant embryos were sectioned transversely at the thoracic level and stained by hematoxylin and eosin. The double mutant embryo shows hemorrhage and edema in the subcutaneous region (brackets in panels A and B). C and D: Electron microscopic analysis of microvessels in E14.5 double mutant embryos. The double mutant endothelial cells were abnormally thin (arrowheads in panel C) and broken (arrows in panels C and D). Scale bars: A and B, 200um; C and D, 1um. | ||||||
| Copyright | This image is from Kono M, J Biol Chem 2004 Jul 9;279(28):29367-73 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:106055 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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