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Targeted Allele Detail
Symbol: Ccng1tm1Noj
Name: cyclin G1; targeted mutation, Hiroshi Nojima
MGI ID: MGI:3619512
Gene: Ccng1  Location: Chr11:40748552-40755311 bp, - strand  Genetic Position: Chr11, 24.42 cM, cytoband B1.1
Germline Transmission:  Earliest citation of germline transmission: J:106744
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-neo cassette replaced a part of the second exon. Mutant mice were subjected to 10 Gy gamma radiation and tissue lysates were analyzed by Western blot. Significant induction of cyclin G1 was observed in irradiated wild-type mice, but was not seen in tissues from cyclin G1 null mice. (J:106744)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ccng1 Mutation:  3 strains or lines available
Original:  J:106744 Kimura SH, et al., Cyclin G1 is involved in G2/M arrest in response to DNA damage and in growth control after damage recovery. Oncogene. 2001 May 31;20(25):3290-300
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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