Analysis Tools
mortality/aging
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• at a dose of 8 GY, nulls continued to die after 10 days with 90% mortality by 30 days, compared to 2/3 survival rate of wild-type and heterozygous animals to 30 days
• at a dose of 4 Gy, 30% of nulls die between 10 and 20 days with similar symptoms to mice which received an 8 Gy dose, compared to 100% survival of wild-type and heterozygotes to 2 months after treatment
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cellular
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• isolated MEFs from null mice show enhanced sensitivity to gamma irradiation, and survival rate was about half that of wild-type after insult
• the growth rate of cultured MEFs after UV irradiation is significantly decreased compared to treated wild-type
• null mutants exhibit swelling of the villi after 4 Gy irradiation, whereas wild-type are almost normal with a mild thickness of villi with lymphocytic infiltration
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digestive/alimentary system
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• null mutants exhibit swelling of the villi after 4 Gy irradiation, whereas wild-type are almost normal with a mild thickness of villi with lymphocytic infiltration
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homeostasis/metabolism
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• at a dose of 8 GY, nulls continued to die after 10 days with 90% mortality by 30 days, compared to 2/3 survival rate of wild-type and heterozygous animals to 30 days
• at a dose of 4 Gy, 30% of nulls die between 10 and 20 days with similar symptoms to mice which received an 8 Gy dose, compared to 100% survival of wild-type and heterozygotes to 2 months after treatment
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