About   Help   FAQ
Targeted Allele Detail
Symbol: Rr27tm2Msb
Name: regulatory region 27; targeted mutation 2, Marisa S Bartolemei
MGI ID: MGI:3617783
Synonyms: H19lxDMD, H19tm2Msb
Gene: Rr27  Location: unknown  Genetic Position: Chr7, Syntenic
Germline Transmission:  Earliest citation of germline transmission: J:105567
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Conditional ready, Modified regulatory region, No functional change)
Mutation:    Insertion
Mutation detailsA targeting vector was designed to insert loxP sites around the 1.6 DMD sequence. A floxed neo was removed via cre mediated recombination. (J:105567)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rr27 Mutation:  6 strains or lines available
Original:  J:105567 Thorvaldsen JL, et al., Developmental profile of H19 differentially methylated domain (DMD) deletion alleles reveals multiple roles of the DMD in regulating allelic expression and DNA methylation at the imprinted H19/Igf2 locus. Mol Cell Biol. 2006 Feb;26(4):1245-58
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.17
The Jackson Laboratory