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Nox1tm1Kkr
Targeted Allele Detail
Nomenclature
Symbol: Nox1tm1Kkr
Name: NADPH oxidase 1; targeted mutation 1, Karl-Heinz Krause
MGI ID: MGI:3616995
Gene: Nox1  Location: ChrX:132987170-133038455 bp, - strand  Genetic Position: ChrX, 55.69 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:105425
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced a 1.9 Kb fragment of the NOX1 gene which encodes exons 3 to 6. RT-PCR confirmed mRNA was absent from the aorta of the hemizygous male mice. (J:105425)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nox1 Mutation:  11 strains or lines available
References
Original:  J:105425 Gavazzi G, et al., Decreased blood pressure in NOX1-deficient mice. FEBS Lett. 2006 Jan 23;580(2):497-504
All:  48 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory