Tnf^M1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Tnf^M1Btlr
• Name: tumor necrosis factor; mutation 1, Bruce Beutler
• MGI ID: MGI:3616888
• Synonyms: PanR1, Tnf^PanR1
• Gene: Tnf Location: Chr17:35418357-35420983 bp, - strand Genetic Position: Chr17, 18.59 cM
• Alliance: Tnf^M1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutation was identified in a screen of G1 progeny of ENU mutagenized male mice for responses to Toll-like receptor- (TLR-) activating ligands. It is a C-to-A transversion in exon 4 which results in replacement of proline by threonine at amino acid 138 of the protein (P138T). Mutant mice produce no active TNF, either secreted or membrane-bound. (J:124642)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tnf Mutation: 46 strains or lines available

References

• Original: J:124642 Rutschmann S, et al., PanR1, a dominant negative missense allele of the gene encoding TNF-alpha (Tnf), does not impair lymphoid development. J Immunol. 2006 Jun 15;176(12):7525-32
• All: 5 reference(s)