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Bhlha15tm2(Kras)Skz
Targeted Allele Detail
Nomenclature
Symbol: Bhlha15tm2(Kras)Skz
Name: basic helix-loop-helix family, member a15; targeted mutation 2, Stephen F Konieczny
MGI ID: MGI:3615274
Synonyms: Mist1KrasG12D
Gene: Bhlha15  Location: Chr5:144127104-144131259 bp, + strand  Genetic Position: Chr5, 83.05 cM, cytoband G2-G3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:105076
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted
Mutation:    Insertion
 
Mutation detailsKras cDNA with a G12D mutation and a PGK-neo cassette were inserted into the locus downstream of the ATG in exon 2 in-frame. (J:105076)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bhlha15 Mutation:  9 strains or lines available
References
Original:  J:105076 Tuveson DA, et al., Mist1-KrasG12D knock-in mice develop mixed differentiation metastatic exocrine pancreatic carcinoma and hepatocellular carcinoma. Cancer Res. 2006 Jan 1;66(1):242-7
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory