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Del(11Irf1-D11Mit23)1Rub
Targeted Allele Detail
Nomenclature
Symbol: Del(11Irf1-D11Mit23)1Rub
Name: deletion, Chr 11, Edward M Rubin 1
MGI ID: MGI:3614966
Synonyms: del11, Del(11Irf1-Csf2)1Rub, Del1Rub
Gene: Del(11Irf1-D11Mit23)1Rub  Location: Chr11:53770014-54236047 bp  Genetic Position: Chr11, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:60187
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted
Mutation:    Intergenic deletion
  Del(11Irf1-D11Mit23)1Rub involves 16 genes/genome features (Irf1, Gm17334, Gm12216 ...) View all
 
Mutation detailsThis engineered 450 kb deletion encompasses exon 10 of Irf1, all of Csf2 and approximately 2 kb of downstream DNA, and 9 known or putative genes between these loci on mouse Chr 11 and/or the homologous region of human Chr 5q31. (J:60187)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Del(11Irf1-D11Mit23)1Rub Mutation:  2 strains or lines available
Notes
Mice homozygous for this deletion and hemizygous for the human YAC transgene Tg(A94G6)1Rub were indistinguishable from wild-type control animals for body weight, liver size, heart size, life span, plasma and hepatic triglyceride levels, and hepatic VLDL triglyceride secretion. As SLC22A5 is the only entire gene present in this transgene, but not in others that failed to complement the homozygous deletion phenotype, the phenotype of Del11Irf1-Csf2)1Rub homozygotes is attributed to loss of this gene.
References
Original:  J:60187 Zhu Y, et al., Genomic interval engineering of mice identifies a novel modulator of triglyceride production. Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1137-42
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/18/2019
MGI 6.14
The Jackson Laboratory