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Ccr5tm1Blck
Targeted Allele Detail
Nomenclature
Symbol: Ccr5tm1Blck
Name: chemokine (C-C motif) receptor 5; targeted mutation 1, Bruno Luckow
MGI ID: MGI:3613371
Synonyms: Ccr5-
Gene: Ccr5  Location: Chr9:124121543-124127183 bp, + strand  Genetic Position: Chr9, 75.05 cM, cytoband F
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:105072
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA lacZ-neo cassette replaced much of the single exon. Absence of transcript was confirmed by RNase-protection assay. (J:105072)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 7 strains available      Cell Lines: 0 lines available
Carrying any Ccr5 Mutation:  23 strains or lines available
References
Original:  J:105072 Luckow B, et al., Reduced intragraft mRNA expression of matrix metalloproteinases Mmp3, Mmp12, Mmp13 and Adam8, and diminished transplant arteriosclerosis in Ccr5-deficient mice. Eur J Immunol. 2004 Sep;34(9):2568-78
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory