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Six6tm1Rsd
Targeted Allele Detail
Summary
Symbol: Six6tm1Rsd
Name: sine oculis-related homeobox 6; targeted mutation 1, Michael G Rosenfeld
MGI ID: MGI:3613016
Synonyms: Six6-
Gene: Six6  Location: Chr12:72986666-72991673 bp, + strand  Genetic Position: Chr12, 30.31 cM
Alliance: Six6tm1Rsd page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:104339
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn IRES-lacZ and pgk-neo cassette replaced the genomic region encoding the sine oculis domain and homeodomain. Western blot confirmed absence of protein. (J:104339)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
In Structures Affected by this Mutation: 10 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Six6 Mutation:  16 strains or lines available
References
Original:  J:104339 Li X, et al., Tissue-specific regulation of retinal and pituitary precursor cell proliferation. Science. 2002 Aug 16;297(5584):1180-3
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory