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Transgenic Allele Detail
Symbol: Sclt1Tg(CAG-sb10)1Dla
Name: sodium channel and clathrin linker 1; transgene insertion 1, David A Largaespada
MGI ID: MGI:3612989
Synonyms: CAGGS-SB10, Tg(ACTB-sb10)1Dla
Gene: Sclt1  Location: Chr3:41626720-41742514 bp, - strand  Genetic Position: Chr3, 19.91 cM, cytoband C
Strain of Origin:  FVB/N
Transgene Type:    Transgenic (Null/knockout, Transposase)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe ubiquitously expressed CAGGS chimeric promoter derived from chicken beta-actin and CMV immediate early promoter sequences drives expression of the sleeping beauty 10 (sb10) transposase. The transgene caused a 3 kb deletion in and inserted into intron 12 of the host gene. RNA-seq confirmed the absence of transcription from exons 13 onward. (J:70414)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sclt1 Mutation:  3 strains or lines available
Original:  J:70414 Dupuy AJ, et al., Transposition and gene disruption in the male germline of the mouse. Genesis. 2001 Jun;30(2):82-8
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory