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Kcnmb4tm1Rwa
Targeted Allele Detail
Nomenclature
Symbol: Kcnmb4tm1Rwa
Name: potassium large conductance calcium-activated channel, subfamily M, beta member 4; targeted mutation 1, Richard W Aldrich
MGI ID: MGI:3611890
Synonyms: Beta4-, BK-Beta4 null
Gene: Kcnmb4  Location: Chr10:116417861-116473878 bp, - strand  Genetic Position: Chr10, 64.73 cM, cytoband D2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:103931
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was replaced with an eGFP-SV40-neo cassette. Elimination of the exon results in the loss of approximately half of the protein-coding region, including the first transmembrane domain. Northern blot did not detect transcript of the wild-type, but did detect transcript using an eGFP probe. (J:103931)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kcnmb4 Mutation:  8 strains or lines available
Notes
Relationship to Human Syndrome: Temporal lobe epilepsy
References
Original:  J:103931 Brenner R, et al., BK channel beta4 subunit reduces dentate gyrus excitability and protects against temporal lobe seizures. Nat Neurosci. 2005 Dec;8(12):1752-9
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory