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Targeted Allele Detail
Symbol: Atxn2tm1Plt
Name: ataxin 2; targeted mutation 1, Stefan M Pulst
MGI ID: MGI:3611805
Synonyms: Sca2-, SCA2tm1SMP
Gene: Atxn2  Location: Chr5:121711609-121814950 bp, + strand  Genetic Position: Chr5, 61.93 cM, cytoband F
Germline Transmission:  Earliest citation of germline transmission: J:103805
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance gene replaced exon 1 by homologous recombination. Exon 1 contained the translation start site. RT-PCR failed to detect transcripts in mutants. Protein was not detected by Western blot or immunocytochemical analyses of various tissues. (J:103805)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atxn2 Mutation:  19 strains or lines available
Original:  J:103805 Kiehl TR, et al., Generation and characterization of Sca2 (ataxin-2) knockout mice. Biochem Biophys Res Commun. 2006 Jan 6;339(1):17-24
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory