Analysis Tools
behavior/neurological
| N |
• ataxia, seizures and abnormal posturing are not observed in mutant mice
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• in a rotarod test, mutant mice exhibit improved performance after the initial trial, however, the latency to fall off was not as improved as control animals
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nervous system
| N |
• no significant brain histological abnormalities are observed
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adipose tissue
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• significantly increased abdominal fat pad size observed at one year of age
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growth/size/body
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• on a high-fat diet, mice exhibit increased body weight beginning at 3 months of age; at one year, mice weight 66% more than control animals
• no abnormal weight gain occurs on a low-fat diet
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liver/biliary system
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• mutant animals exhibit more severe liver steatosis than control mice at one year of age
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endocrine/exocrine glands
 |
• variable severity; bilateral enlargement is observed with some animals exhibiting very little enlargement and others that exhibit a resulting enlarged abdomen
• seminal vesicle histology is normal and no obstruction of seminal vesicle outflow or of the prostate are seen
• fertility is normal
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reproductive system
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• variable severity; bilateral enlargement is observed with some animals exhibiting very little enlargement and others that exhibit a resulting enlarged abdomen
• seminal vesicle histology is normal and no obstruction of seminal vesicle outflow or of the prostate are seen
• fertility is normal
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