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Sphk2tm1Rlp
Targeted Allele Detail
Nomenclature
Symbol: Sphk2tm1Rlp
Name: sphingosine kinase 2; targeted mutation 1, Richard L Proia
MGI ID: MGI:3611080
Synonyms: SK2-, Sphk2-
Gene: Sphk2  Location: Chr7:45358891-45367426 bp, - strand  Genetic Position: Chr7, 29.45 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:103755
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA lacZ-neo cassette replaced half of exon 4 through the end of exon 7 by homologous recombination. RT-PCR analysis of total RNA form adult tissues failed to detect transcript in mutants. (J:103755)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Sphk2 Mutation:  27 strains or lines available
References
Original:  J:103755 Mizugishi K, et al., Essential role for sphingosine kinases in neural and vascular development. Mol Cell Biol. 2005 Dec;25(24):11113-21
All:  48 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory