Analysis Tools
normal phenotype
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• homozygotes are fertile, have normal longevity and histological analysis of major organs failed to reveal any abnormalities
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Allele Symbol Allele Name Allele ID |
Sphk2tm1Rlp targeted mutation 1, Richard L Proia MGI:3611080 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• homozygotes are fertile, have normal longevity and histological analysis of major organs failed to reveal any abnormalities
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 17% of embryos are not viable at E11.5, 70% die by E12.5 and none survive past E13.5
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• remodeling defects of blood vessels in the head are apparent at E10.5. showing the formation of enlarged, dilated blood vessels and an aberrant anastomotic network
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• wall of the dorsal aorta is poorly developed at E11.5
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• endothelial cells are severely defective in all blood vessels in the mesenchymal region of the head and some contain vacuoles
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• the smooth muscle covering of the aorta is patchy and incomplete
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• severely affected embryos exhibit widespread hemorrhaging in areas other than the brain such as the spinal cord and mandible
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• seen in some embryos
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• exhibit cranial hemorrhage by E11.5 and E12.5, predominately in the cranial mesenchymal region
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• hemorrhaging in the cranial mesenchymal region is sometimes accompanied by intraventricular hemorrhages
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• seen in some embryos
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• the smooth muscle covering of the aorta is patchy and incomplete
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• exhibit cranial hemorrhage by E11.5 and E12.5, predominately in the cranial mesenchymal region
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• hemorrhaging in the cranial mesenchymal region is sometimes accompanied by intraventricular hemorrhages
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• seen in some embryos
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• apoptosis is increased in the neuroepithelium of the rhombencephalon
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• apoptosis is increased in the neuroepithelium of the mesencephalon
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• apoptosis is increased in the neuroepithelium of the mesencephalon and the rhombencephalon
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• embryos exhibit a very thin, poorly developed wall of neuroepithelium and an irregularly shaped neuroepithelial layer in the whole brain
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• embryos exhibit a very thin, poorly developed wall of neuroepithelium
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• impaired anterior neural tube closure
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• ventricular dilation at E11.5
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• seen in 18% of embryos at E10.5, 13% at E11.5 and in 20% at E12.5, however do not observe spina bifida
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• embryos exhibit a very thin, poorly developed wall of neuroepithelium and an irregularly shaped neuroepithelial layer in the whole brain
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• embryos exhibit a very thin, poorly developed wall of neuroepithelium
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• impaired anterior neural tube closure
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• seen in some embryos
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• apoptosis is increased in the neuroepithelium of the rhombencephalon
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• apoptosis is increased in the neuroepithelium of the mesencephalon
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• apoptosis is increased in the neuroepithelium of the mesencephalon and the rhombencephalon
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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