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Targeted Allele Detail
Symbol: Angptl4tm1Akos
Name: angiopoietin-like 4; targeted mutation 1, Anja Koster
MGI ID: MGI:3610613
Synonyms: Angptl4-
Gene: Angptl4  Location: Chr17:33774900-33781575 bp, - strand  Genetic Position: Chr17, 17.98 cM
Germline Transmission:  Earliest citation of germline transmission: J:103363
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsTargeting vector sequences replaced 2.05 kb of sequence including most of exon 1 containing the start codon and encoding the signal peptide and exons 2 and 3. Northern blot failed to detect transcript in mutant white adipose tissue. (J:103363)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Angptl4 Mutation:  20 strains or lines available
Original:  J:103363 Koster A, et al., Transgenic angiopoietin-like (angptl)4 overexpression and targeted disruption of angptl4 and angptl3: regulation of triglyceride metabolism. Endocrinology. 2005 Nov;146(11):4943-50
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory