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Angptl4tm1Akos
Targeted Allele Detail
Nomenclature
Symbol: Angptl4tm1Akos
Name: angiopoietin-like 4; targeted mutation 1, Anja Koster
MGI ID: MGI:3610613
Synonyms: Angptl4-
Gene: Angptl4  Location: Chr17:33773750-33781575 bp, - strand  Genetic Position: Chr17, 17.98 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:103363
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsTargeting vector sequences replaced 2.05 kb of sequence including most of exon 1 containing the start codon and encoding the signal peptide and exons 2 and 3. Northern blot failed to detect transcript in mutant white adipose tissue. (J:103363)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Angptl4 Mutation:  17 strains or lines available
References
Original:  J:103363 Koster A, et al., Transgenic angiopoietin-like (angptl)4 overexpression and targeted disruption of angptl4 and angptl3: regulation of triglyceride metabolism. Endocrinology. 2005 Nov;146(11):4943-50
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory