Sp7^tm2Crm
Targeted Allele Detail

Summary

• Symbol: Sp7^tm2Crm
• Name: Sp7 transcription factor 7; targeted mutation 2, Benoit de Crombrugghe
• MGI ID: MGI:3608932
• Synonyms: Osx^flox
• Gene: Sp7 Location: Chr15:102265038-102275498 bp, - strand Genetic Position: Chr15, 57.51 cM
• Alliance: Sp7^tm2Crm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102495
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites flanked exon 2. An FRT-flanked PGK-neo and IRES-EGFP-pA cassette were inserted at the second loxP site and subsequently removed by crossing with FLP recombinase expressing mice. (J:102495)

Expression

In Mice Carrying this Mutation:	5 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sp7 Mutation: 21 strains or lines available

References

• Original: J:102495 Akiyama H, et al., Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors. Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14665-70
• All: 21 reference(s)