Phenotypes associated with this allele

• Allele Symbol: Sp7^tm2Crm
• Allele Name: targeted mutation 2, Benoit de Crombrugghe
• Allele ID: MGI:3608932
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Sox9^tm3(cre)Crm/Sox9^+ Sp7^tm1Crm/Sp7^tm2Crm	involves: 129S7/SvEvBrd * C57BL/6 * SJL	MGI:3610909

Genotype
MGI:3610909

cn1

• Allelic Composition: Sox9^tm3(cre)Crm/Sox9⁺; Sp7^tm1Crm/Sp7^tm2Crm
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:102495 )

• die in the immediate postnatal period due to the absence of bones

skeleton

abnormal limb bone morphology ( J:102495 )

• limb skeletons are hypoplastic, bent, and often deformed

abnormal axial skeleton morphology ( J:102495 )

abnormal rib morphology ( J:102495 )

• ribs are bent and deformed

abnormal vertebrae morphology ( J:102495 )

• vertebrae are bent and deformed

abnormal trabecular bone morphology ( J:102495 )

• endochondral skeletal elements such as the humerus have no bone trabeculae or bone collars

abnormal skeleton development ( J:102495 )

abnormal osteoblast differentiation ( J:102495 )

• osteoblast differentiation is arrested

abnormal bone ossification ( J:102495 )

• exhibit a decrease in endochondral and intramembranous ossification

• skeletal elements formed by endochondral bone formation, including the ribs, limb skeletons, and vertebrae are hypoplastic, bent, and often deformed

abnormal bone mineralization ( J:102495 )

• virtually no mineralization in any facial and skull bones generated by intramembranous bone formation, although very small parts of the maxilla, mandible, and parietal bones were calcified

limbs/digits/tail

abnormal limb bone morphology ( J:102495 )

• limb skeletons are hypoplastic, bent, and often deformed

cellular

abnormal osteoblast differentiation ( J:102495 )

• osteoblast differentiation is arrested