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Cpt1atm1Pwo
Targeted Allele Detail
Nomenclature
Symbol: Cpt1atm1Pwo
Name: carnitine palmitoyltransferase 1a, liver; targeted mutation 1, Philip A Wood
MGI ID: MGI:3606251
Synonyms: Cpt-1atm1Uab
Gene: Cpt1a  Location: Chr19:3372334-3435733 bp, + strand  Genetic Position: Chr19, 3.08 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101934
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting construct was designed to replace exons 11-18 with a neomycin resistance gene in the reverse orientation to transcription. FISH confirmed correct targeting of the locus. (J:101934)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cpt1a Mutation:  38 strains or lines available
References
Original:  J:101934 Nyman LR, et al., Homozygous carnitine palmitoyltransferase 1a (liver isoform) deficiency is lethal in the mouse. Mol Genet Metab. 2005 Sep-Oct;86(1-2):179-87
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/14/2022
MGI 6.19
The Jackson Laboratory