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Smarca4tm1.2Pcn
Targeted Allele Detail
Nomenclature
Symbol: Smarca4tm1.2Pcn
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; targeted mutation 1.2, Pierre Chambon
MGI ID: MGI:3605892
Synonyms: Brg1F, brg1FL, Brg1L2, Brg1lox, Smarca4tm1Grc, Smarca4tm1Pcn, SNF2BetaL:La
Gene: Smarca4  Location: Chr9:21616169-21704217 bp, + strand  Genetic Position: Chr9, 7.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:66861
Parent Cell Line:  P1 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA single loxP site was inserted upstream of exon 18 and a floxed hygromycin resistance cassette was inserted downstream of exon 19. The hygromycin resistance cassette was selectively excised from correctly targeted ES cells by transient transfection with a cre-expression vector. Exons 18 and 19, encoding part of the ATPase-helicase motifs, were thus flanked by loxP sites in the resulting ES cells. (J:42997, J:101729)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Smarca4 Mutation:  51 strains or lines available
References
Original:  J:66861 Bultman S, et al., A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes. Mol Cell. 2000 Dec;6(6):1287-95
All:  35 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/17/2015
MGI 5.21
The Jackson Laboratory