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Gabra4tm1Dgen
Targeted Allele Detail
Nomenclature
Symbol: Gabra4tm1Dgen
Name: gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4; targeted mutation 1, Deltagen
MGI ID: MGI:3604588
Gene: Gabra4  Location: Chr5:71569749-71658308 bp, - strand  Genetic Position: Chr5, 38.08 cM
Mutation
origin
Mutant Cell Line:  3066
Germline Transmission:  Earliest citation of germline transmission: J:101679
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Project Collection: Deltagen
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Disruption caused by insertion of vector
 
Mutation detailsA bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. RT-PCR analysis detects a high level of gene transcript in the brain, cortex, subcortical region, cerebellum, olfactory bulb, pancreas and pituitary gland and lower levels in brainstem, spinal cord, eye, Harderian glands, lung, kidney, spleen, lymph nodes, skin, urinary bladder, adrenal gland, salivary gland, tongue, stomach, small intestine, testis, epididymis, seminal vesicle, coagulating gland, prostate gland, ovaries, uterus and white fat. Beta-galactosidase expression from this allele is detectable in brain, spinal cord, pancreas, pituitary gland and salivary glands.
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 73 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gabra4 Mutation:  22 strains or lines available
Notes
See also, data as provided by Deltagen, Inc.
References
Original:  J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory