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Targeted Allele Detail
Symbol: Gabrptm1Dgen
Name: gamma-aminobutyric acid (GABA) A receptor, pi; targeted mutation 1, Deltagen
MGI ID: MGI:3604585
Gene: Gabrp  Location: Chr11:33500781-33528959 bp, - strand  Genetic Position: Chr11, 19.21 cM
Alliance: Gabrptm1Dgen page
Mutant Cell Line:  6646
Germline Transmission:  Earliest citation of germline transmission: J:101679
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Project Collection: Deltagen
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Disruption caused by insertion of vector
Mutation detailsA bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. RT-PCR analysis detects a high level of gene transcript in the gallbladder, moderate levels in lung, skin, seminal vesicle, prostate gland, ovary and uterus and low levels in subcortical region, olfactory bulb, eye, Harderian glands, liver, pancreas, kidney, thymus, urinary bladder, pituitary gland, salivary gland, tongue, stomach, small intestine, large intestine, cecum, testis, epididymis, coagulating gland and white fat. Beta-galactosidase expression from this allele is detectable in brain, spinal cord, thymus, lung, liver, pancreas, kidney, trachea, skeletal muscle, skin, testis, uterus and cervix. Most striking expression was detected in bronchial and tracheal epithelium. Staining was observed in different tissue and cell types, including epithelium and neurons.
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 40 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gabrp Mutation:  16 strains or lines available
See also, data as provided by Deltagen, Inc.
Original:  J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory