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Gpr37tm1Dgen
Targeted Allele Detail
Nomenclature
Symbol: Gpr37tm1Dgen
Name: G protein-coupled receptor 37; targeted mutation 1, Deltagen
MGI ID: MGI:3604579
Gene: Gpr37  Location: Chr6:25665878-25690729 bp, - strand  Genetic Position: Chr6, 11.65 cM
Mutation
origin
Mutant Cell Line:  5029
Germline Transmission:  Earliest citation of germline transmission: J:101679
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Project Collection: Deltagen
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. RT-PCR analysis detects a high level of gene transcript in the whole brain, subcortical region, brainstem and spinal cord, moderate levels in cortex, cerebellum, olfactory bulb, eye, testis and ovary and low levels in cortex, cerebellum, olfactory bulb, eye, Harderian glands, lung, liver, pancreas, kidney, spleen, thymus, lymph nodes, skin, gallbladder, urinary bladder, pituitary gland, adrenal gland, salivary gland, tongue, stomach, small intestine, colon, coagulating gland, prostate gland, uterus and white fat. Beta-galactosidase expression from this allele is detectable in brain, spinal cord, eyes, skin, and testis. Moderate to strong lacZ expression was detected in cells scattered throughout the brain and spinal cord. In the brain, most striking expression was detected in white matter, thalamus and brainstem. In the spinal cord, gray matter showed moderate, scattered staining while only a few cells in the white matter showed weak staining. Strong expression was detected in the ganglion cell and inner nuclear layers of the retina. In skin, strong staining was observed in a few cells surrounding hair follicles. Strong expression was also detected in the seminiferous tubules of the testis.
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 44 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gpr37 Mutation:  18 strains or lines available
Notes
See also, data as provided by Deltagen, Inc.
References
Original:  J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005;
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory