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Targeted Allele Detail
Symbol: Tgfbr1tm1Dgen
Name: transforming growth factor, beta receptor I; targeted mutation 1, Deltagen
MGI ID: MGI:3604556
Gene: Tgfbr1  Location: Chr4:47353222-47414926 bp, + strand  Genetic Position: Chr4, 26.02 cM
Alliance: Tgfbr1tm1Dgen page
Mutant Cell Line:  4398
Germline Transmission:  Earliest citation of germline transmission: J:101679
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Project Collection: Deltagen
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsA bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. While RT-PCR analysis detects a gene transcript in most tissues analyzed, beta-galactosidase expression from this allele is detectable in all organs examined, with most striking expression in aorta and other blood vessels, heart valve, renal papilla, muscularis of the urinary bladder, corpus lutea in the ovary and in testis.
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 129 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tgfbr1 Mutation:  27 strains or lines available
See also, data as provided by Deltagen, Inc.
Original:  J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory