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Targeted Allele Detail
Symbol: Fzd8tm1Dgen
Name: frizzled class receptor 8; targeted mutation 1, Deltagen
MGI ID: MGI:3604555
Gene: Fzd8  Location: Chr18:9212856-9216201 bp, + strand  Genetic Position: Chr18, 4.91 cM
Alliance: Fzd8tm1Dgen page
Mutant Cell Line:  6814
Germline Transmission:  Earliest citation of germline transmission: J:101679
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Project Collection: Deltagen
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Disruption caused by insertion of vector
Mutation detailsA bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. RT-PCR analysis detects a high level of gene transcript in the pituitary gland, moderate levels in brain, subcortical region, cerebellum, olfactory bulb, spinal cord, eye, Harderian glands, heart, lung, liver, kidney, spleen, skin, gallbladder, urinary bladder, adrenal gland, large intestine, testis, epididymis, coagulating gland, prostate gland, ovaries, uterus and white fat and low levels in cortex, brainstem, pancreas, thymus, lymph nodes, salivary gland, skeletal muscle, tongue, stomach, small intestine, cecum and seminal vesicle. Beta-galactosidase expression from this allele is detectable in many of the organs examined. Most striking staining was detected in the aorta and other blood vessels, the capsule of the adrenal gland, tracheal cartilage and neural ganglia. Staining was observed in different tissue and cell types, including neurons, epithelium, cartilage and blood vessels.
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 83 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fzd8 Mutation:  20 strains or lines available
See also, data as provided by Deltagen, Inc.
Original:  J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory