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Efemp2tm1Dgen
Targeted Allele Detail
Nomenclature
Symbol: Efemp2tm1Dgen
Name: epidermal growth factor-containing fibulin-like extracellular matrix protein 2; targeted mutation 1, Deltagen
MGI ID: MGI:3604551
Synonyms: Fbln4-, fibulin-4-
Gene: Efemp2  Location: Chr19:5473973-5481853 bp, + strand  Genetic Position: Chr19, 4.33 cM, cytoband A
Efemp2tm1Dgen/Efemp2+ mice exhibit abnormal aorta morphology

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Mutant Cell Line:  2561 (Deltagen)
Germline Transmission:  Earliest citation of germline transmission: J:101679
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Project Collection: Deltagen
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. While RT-PCR analysis detects a gene transcript in all tissues tested, strong beta-galactosidase expression from this alleleis detectable in brain, spinal cord, eyes, Harderian glands, thymus, spleen, lymph nodes, aorta, heart, lung, liver, gallbladder, pancreas, kidney, urinary bladder, trachea, larynx, esophagus, thyroid gland, pituitary gland, adrenal glands, salivary glands, tongue, skeletal muscle, skin, male and female reproductive systems. In many tissues lacZ is expressed in smooth muscle cells.
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 122 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Efemp2 Mutation:  4 strains or lines available
Notes
See also, data as provided by Deltagen, Inc.

References
Original:  J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005;
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory