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Esrrgtm1Dgen
Targeted Allele Detail
Nomenclature
Symbol: Esrrgtm1Dgen
Name: estrogen-related receptor gamma; targeted mutation 1, Deltagen
MGI ID: MGI:3604501
Synonyms: ERRgamma G-strain
Gene: Esrrg  Location: Chr1:187608791-188214885 bp, + strand  Genetic Position: Chr1, 91.83 cM, cytoband H5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101679
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Project Collection: Deltagen
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA lacZ-neomycin cassette was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase and nucleotides from base 586 to 610 of exon 2 were deleted. RT-PCR analysis detects a high level of gene transcript in salivary gland and stomach, moderate levels in whole brain, cortex, subcortical region, cerebellum, brainstem, olfactory bulb, spinal cord, eye, Harderian glands, heart, kidney, lymph nodes, gallbladder, pituitary gland, adrenal gland, tongue, epididymis, coagulating gland, prostate gland and white fat and low levels in lung, liver, pancreas, spleen, thymus, bone marrow, skin, urinary bladder, skeletal muscle, small intestine, cecum, colon, testis, seminal vesicle, ovary and uterus. Beta-galactosidase expression from this allele is detectable in central nervous system, eyes, heart, kidney and cervix. Strong to very strong lacZ expression was detected throughout the whole mount brain as well as in sections of cerebrum, cerebellum, brainstem and spinal cord. In the eyes, very strong expression was detected in retina and ciliary body with moderate to strong expression in lens. Very strong staining was also observed throughout the myocardium. In kidney, very strong expression was detected throughout the cortex and medulla and in some cells of the papilla. The cervix shows very strong staining in the stratified squamous epithelium nearest the cervical canal. (J:156955)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 91 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Esrrg Mutation:  13 strains or lines available
Notes
See also, data as provided by Deltagen, Inc.
References
Original:  J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005;
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory