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Frzbtm1Dgen
Targeted Allele Detail
Nomenclature
Symbol: Frzbtm1Dgen
Name: frizzled-related protein; targeted mutation 1, Deltagen
MGI ID: MGI:3604496
Gene: Frzb  Location: Chr2:80411970-80447625 bp, - strand  Genetic Position: Chr2, 48.13 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101679
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Project Collection: Deltagen
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Disruption caused by insertion of vector
 
Mutation detailsA bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. RT-PCR analysis detects a high level of gene transcript in the whole brain, olfactory bulb, kidney, skeletal muscle and testis and low levels in cortex, subcortical region, cerebellum, brainstem, spinal cord, eye, heart, liver, pancreas, spleen, thymus, lymph nodes, skin, gallbladder, urinary bladder, pituitary gland, adrenal gland, salivary gland, tongue, epididymis, seminal vesicle, coagulating gland, prostate gland, ovary and uterus. Beta-galactosidase expression from this allele is detectable in brain. Strong staining was observed in olfactory bulb. Staining was also observed in regions of hypothalamus and thalamus. On coronal sections of cerebrum, moderate expression was detected in the ventral region of the third ventricle.
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 36 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Frzb Mutation:  15 strains or lines available
Notes
See also, data as provided by Deltagen, Inc.
References
Original:  J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory