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Acvrl1tm1Dgen
Targeted Allele Detail
Nomenclature
Symbol: Acvrl1tm1Dgen
Name: activin A receptor, type II-like 1; targeted mutation 1, Deltagen
MGI ID: MGI:3604490
Gene: Acvrl1  Location: Chr15:101128522-101145336 bp, + strand  Genetic Position: Chr15, 56.41 cM, cytoband F3
Abnormal cardiac morphology, pericardial effusion, and growth retardation in Tmem100tm1.1Ysai and Acvrl1tm1Dgen homozygotes

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Mutant Cell Line:  4068 (Deltagen)
Germline Transmission:  Earliest citation of germline transmission: J:101679
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Project Collection: Deltagen
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. The highest levels of RNA transcripts are detectable in lung. Lower levels of RNA transcripts are also detectable in all other tissues analyzed: brain, cortex, subcortical region, cerebellum, brainstem, olfactory bulb, spinal cord, eye, Harderian glands, heart, liver, pancreas, kidney, spleen, thymus, lymph nodes, bone marrow, skin, gallbladder, urinary bladder, pituitary gland, adrenal gland, salivary gland, skeletal muscle, tongue, stomach, small intestine, large intestine, cecum, testis, epididymis, seminal vesicle, coagulating gland, prostate gland, ovaries, uterus and white fat. LacZ (beta-galactosidase) expression is detectable in all tissues examined. (J:101679)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 119 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Acvrl1 Mutation:  1 strain or line available
Notes
See also, data as provided by Deltagen, Inc.

References
Original:  J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005;
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/24/2015
MGI 5.21
The Jackson Laboratory