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Transgene Detail
Symbol: Tg(Prdx6)153Pgn
Name: transgene insertion 153, Beverly J Paigen
MGI ID: MGI:3604080
Synonyms: Prdx6129/SvJ-Tg
Transgene: Tg(Prdx6)153Pgn  Location: unknown  
Strain of Origin:  C57BL/6
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(Prdx6)153Pgn expresses 1 gene
Mutation details The transgene consists of the entire Prdx6 sequence (approximately 10 kB) and 6.6 kB of upstream sequence from the diet-induced atherosclerosis resistant 129X1/SvJ mouse strain. The 129X1/SvJ sequence contains an amino acid variant at position 124 encoding aspartic acid rather than the alanine found in C57BL/6. Southern blot analysis distinguishes between endogenous and transgenic genes. Lines 153 and 105 contained multiple copies of the transgene and were selected for further analysis. Western blot, ELISA and immunohistochemical analysis reveal higher levels of PRDX6 expression in many tissues, especially liver and aorta, than is found in tissues normally expressing the gene. (J:86528)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:86528 Phelan SA, et al., Overexpression of Prdx6 reduces H2O2 but does not prevent diet-induced atherosclerosis in the aortic root. Free Radic Biol Med. 2003 Nov 1;35(9):1110-20
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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