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Casp7tm1Flv
Targeted Allele Detail
Nomenclature
Symbol: Casp7tm1Flv
Name: caspase 7; targeted mutation 1, Richard A Flavell
MGI ID: MGI:3603317
Synonyms: Casp7-
Gene: Casp7  Location: Chr19:56397129-56442344 bp, + strand  Genetic Position: Chr19, 51.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:59875
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe targeting construct replaces exons 2 and 3 with a neomycin resistance cassette, and also results in a frame-shift. Western blot analysis showed absence of caspase 7 expression in homozygous mice. (J:105496)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Casp7 Mutation:  4 strains or lines available
References
Original:  J:59875 Zheng TS, et al., Caspase knockouts: matters of life and death. Cell Death Differ. 1999 Nov;6(11):1043-53
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory