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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Casp7tm1Flv
targeted mutation 1, Richard A Flavell
MGI:3603317
Summary 4 genotypes


Genotype
MGI:3810972
hm1
Allelic
Composition		 Casp7tm1Flv/Casp7tm1Flv
Genetic
Background		 B6.129S6-Casp7tm1Flv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp7tm1Flv mutation (1 available); any Casp7 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased fibroblast apoptosis ( J:105496 )
• mouse embryonic fibroblasts (MEFs) exhibit a slight decrease in apoptosis rates following exposure to various insults
• following UV irradiation and staurosporine treatment, MEFs exhibit increased survival compared to wild type or Casp7tm1Flv MEFs

immune system
immune system phenotype ( J:105496 )
N
• lymphoid development and T cell apoptosis are normal




Genotype
MGI:3603540
hm2
Allelic
Composition		 Casp7tm1Flv/Casp7tm1Flv
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp7tm1Flv mutation (1 available); any Casp7 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:101037 )
N
• lenses appear grossly normal
• lens extracts display normal levels of lysis of fluorogenic substrate DEVD-AMC




Genotype
MGI:3810970
cx3
Allelic
Composition		 Casp3tm1Flv/Casp3tm1Flv
Casp7tm1Flv/Casp7+
Genetic
Background		 B6.129S-Casp3tm1Flv Casp7tm1Flv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp3tm1Flv mutation (1 available); any Casp3 mutation (31 available)
Casp7tm1Flv mutation (1 available); any Casp7 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased sensitivity to induced cell death ( J:105496 )
• mouse embryonic fibroblasts (MEFs) subjected to UV irradiation and staurosporine exhibit distorted chromosome condensation and nuclear fragmentation is absent unlike in similarly treated MEFs
decreased thymocyte apoptosis ( J:105496 )
• following injection of fetal liver cells into a RAG-deficient background, thymocyte apoptosis induced by mitochondrial pathways is decreased although not as much as in Casp3tm1Flv Casp7tm1Flv homozygous T cells
decreased fibroblast apoptosis ( J:105496 )
• apoptosis is decreased in mouse embryonic fibroblasts (MEFs) subjected to UV irradiation and staurosporine comapred to in wild-type MEFs
• MEFs exhibit decreased apoptosis following stimulation of the death receptor pathway that is intermediate to the response observed in Casp3tm1Flv Casp7tm1Flv homozygous MEFs

immune system
decreased thymocyte apoptosis ( J:105496 )
• following injection of fetal liver cells into a RAG-deficient background, thymocyte apoptosis induced by mitochondrial pathways is decreased although not as much as in Casp3tm1Flv Casp7tm1Flv homozygous T cells

hematopoietic system
decreased thymocyte apoptosis ( J:105496 )
• following injection of fetal liver cells into a RAG-deficient background, thymocyte apoptosis induced by mitochondrial pathways is decreased although not as much as in Casp3tm1Flv Casp7tm1Flv homozygous T cells

endocrine/exocrine glands
decreased thymocyte apoptosis ( J:105496 )
• following injection of fetal liver cells into a RAG-deficient background, thymocyte apoptosis induced by mitochondrial pathways is decreased although not as much as in Casp3tm1Flv Casp7tm1Flv homozygous T cells




Genotype
MGI:3810971
cx4
Allelic
Composition		 Casp3tm1Flv/Casp3tm1Flv
Casp7tm1Flv/Casp7tm1Flv
Genetic
Background		 B6.129S-Casp3tm1Flv Casp7tm1Flv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp3tm1Flv mutation (1 available); any Casp3 mutation (31 available)
Casp7tm1Flv mutation (1 available); any Casp7 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:105496 )
• though present in Mendelian ratios at E20, mice die rapidly after birth
postnatal lethality, complete penetrance ( J:105496 )
• mice die rapidly after birth and by P10 to P14 no mice are alive

cellular
decreased sensitivity to induced cell death ( J:105496 )
• mouse embryonic fibroblasts (MEFs) subjected to UV irradiation and staurosporine fail to exhibit evidence of normal apoptosis 24hrs after treatment unlike in wild type MEFs
decreased thymocyte apoptosis ( J:105496 )
• following injection of fetal liver cells into a RAG-deficient background, thymocyte apoptosis induced by mitochondrial pathways is decreased
• however, thymocytes are still sensitive to death receptor mediated apoptosis
decreased fibroblast apoptosis ( J:105496 )
• mouse embryonic fibroblasts (MEFs) subjected to UV irradiation and staurosporine fail to undergo apoptosis
• MEFs exhibit decreased apoptosis following stimulation of the death receptor pathway
• following induction of apoptosis, MEFs fail to exhibit a loss of mitochondrial membrane potential

cardiovascular system
abnormal heart ventricle morphology ( J:105496 )
• at E20, the ventricular wall is disorganized and noncompacted

nervous system
exencephaly ( J:105496 )
• in 10% of mice

immune system
decreased thymocyte apoptosis ( J:105496 )
• following injection of fetal liver cells into a RAG-deficient background, thymocyte apoptosis induced by mitochondrial pathways is decreased
• however, thymocytes are still sensitive to death receptor mediated apoptosis

hematopoietic system
decreased thymocyte apoptosis ( J:105496 )
• following injection of fetal liver cells into a RAG-deficient background, thymocyte apoptosis induced by mitochondrial pathways is decreased
• however, thymocytes are still sensitive to death receptor mediated apoptosis

endocrine/exocrine glands
decreased thymocyte apoptosis ( J:105496 )
• following injection of fetal liver cells into a RAG-deficient background, thymocyte apoptosis induced by mitochondrial pathways is decreased
• however, thymocytes are still sensitive to death receptor mediated apoptosis




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory